HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 849781Generated: October 27, 2026
Sodium Hydroxide → N'-t-butyl-N-isonicotinyl-N'-benzoylhydrazine
https://huagongshe.com/reaction/849781
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| Reactant | N-(tert-butyl)benzohydrazide | HCID 1275961 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N'-t-butyl-N-isonicotinyl-N'-benzoylhydrazine | HCID 53730014 | — |
Reaction Steps
A solution of N'-t-butyl-N'-benzoylhydrazine (0.5 g, 0.00026 mol) in 10 ml of toluene was treated with 50% sodium hydroxide (0.6 g) followed by isonicotinyl chloride hydrochloride (0.47 g, 0.0026 mol). The mixture was stirred at 23° C. overnight. The solids were removed by filtration and washed with water followed by ether to afford N'-t-butyl-N-isonicotinyl-N'-benzoylhydrazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06013836 |
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| Source dataset | uspto-grants-2000_01 |
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| ORD ID | ord-31d408072bc54da39f7f9d26ac652331 |
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| Source note | uspto-grants-2000_01 |
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