HCID 54137068, compound → HCID 59875630, compound

HRID 849821Notes

Reaction equation

HRID 849821 reaction equation
C([C@@H](C[C:29]1[CH:38]=[CH:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=1)/C=C/[C@H](NC(C1CCNCC1)=O)CC1C=CC2C(=CC=CC=2)C=1)(=O)N.NCCCC[C@H](NC([C@H](OC[C@H](NC(=O)C1C=CC=C(CN)C=1)C[C:65]1[CH:74]=[CH:73][C:72]2[C:67](=CC=CC=2)[CH:66]=1)CC1C=CC=CC=1)=O)C(=O)N(C)C.NCCCC[C@H]([NH:97][C:98]([C@@H:100]([CH2:127]C1C=CC=CC=1)[CH2:101][C:102](=O)[C@H:103]([NH:115][C:116](=[O:125])[C:117]1[CH:122]=[CH:121][CH:120]=[C:119]([CH2:123][NH2:124])[CH:118]=1)[CH2:104]C1C=CC2C(=CC=CC=2)C=1)=[O:99])C(=O)N(C)C.N[CH2:135][CH2:136][CH2:137][CH2:138][C@H](NC([C@@H](CC1C=CC=CC=1)C[C@@H](O)[C@H](NC(=O)C1C=CC=C(CN)C=1)CC1C=CC2C(=CC=CC=2)C=1)=O)C(=O)N(C)C.C(OC(C1N=C([C@H](N(C)C(=O)[C@H](NC(C2CCNCC2)=O)CC2C=CC3C(=CC=CC=3)C=2)CC2C=CC3C(=CC=CC=3)C=2)ON=1)=O)C.C(OC(C1N=C([C@H](N(C(=O)[C@H](NC(=O)C2C=CC=C(CN)C=2)CC2C=CC3C(=CC=CC=3)C=2)C)CC2C=CC3C(=CC=CC=3)C=2)ON=1)=O)C.NCC1C=C(C=CC=1)C(N[C@H](CC1C=CC2C(=CC=CC=2)C=1)C(N([C@@H](C1OC(C(N)=O)=NN=1)CC1C=CC=CC=1)C)=O)=O>>[NH2:124][CH2:123][C:119]1[CH:118]=[C:117]([CH:122]=[CH:121][CH:120]=1)[C:116]([NH:115][C@H:103]([CH2:104][C:65]1[CH:74]=[CH:73][C:72]2[C:67](=[CH:135][CH:136]=[CH:137][CH:138]=2)[CH:66]=1)/[CH:102]=[CH:101]/[C@@H:100]([C:98](=[O:99])[NH2:97])[CH2:127][C:29]1[CH:38]=[CH:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=1)=[O:125]

Participants

8

Reactant 7

HCID 54137068HCID 54137068, compoundHCID 54299686HCID 54299686, compoundHCID 54382822HCID 54382822, compoundHCID 54442720HCID 54442720, compoundHCID 54456493HCID 54456493, compoundHCID 54461014HCID 54461014, compoundHCID 59875618HCID 59875618, compound

Product 1

HCID 59875630HCID 59875630, compound

Procedure

##STR19## Piperidine-4-carboxylic acid ((1R,2E,4S)-4-carbamoyl-5-(2-naphthyl)-1-(2-naphthyl)methylpent-2-enyl)amide: ##STR20## N-((1R)-1-((1R)-1-((1S)-5-Amino-1-(dimethylcarbamoyl)pentylcarbamoyl)-2-phenylethoxy)methyl-2-(2-naphthyl)ethyl)-3-aminomethylbenzamide: ##STR21## N-((1R,4S)-4-(((1S)-5-Amino-1-(dimethylcarbamoyl)pentyl)carbamoyl)-1-((2-naphthyl)methyl)-2-oxo-5-phenylpentyl)-3-aminomethylbenzamide: ##STR22## N-((1R,2R,4S)-4-(((1S)-5-Amino-1-(dimethylcarbamoyl)pentyl)carbamoyl)-2-hydroxy-1-((2-naphthyl)methyl)-5-phenylpentyl)-3-aminomethylbenzamide: ##STR23## Piperidine-3-carboxylic acid ((1R,2R,4S)-4-(((1S)-5-amino-1-(dimethylcarbamoyl)pentyl)carbamoyl)-2-hydroxy-1-(2-naphthyl)methyl)-5-phenylpentyl)amide: ##STR24## 5-((1R)-1-(N-Methyl-N-((2R)-3-(2-naphthyl)-2-(piperidine-4-carbonylamino)propionyl)amino)-2-(2-naphthyl)ethyl)-[1,2,4]oxadiazole-3-carboxylic acid ethylester: ##STR25## 5-((1R)-1-(N-((2R)-2-(3-Aminomethylbenzoylamino)-3-(2-naphthyl)propionyl)-N-methylamino)-2-(2-naphthyl)ethyl)-[1,2,4]oxadiazole-3-carboxylic acid ethylester: ##STR26## 5-((1R)-1-(N-((2R)-2-(3-Aminomethylbenzoylamino)-3-(2-naphthyl)propionyl)-N-methylamino)-2-phenylethyl)-[1,3,4]oxadiazole-2-carboxylic acid amide: ##STR27##

Sources & evidence

ORD record
ord-a2a0463cade7480d83e8a6718c4a12e0
Source dataset
uspto-grants-2000_01
Patent number
US06013658

Reaction notes

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