Hydrochloric Acid → (2R)-2-amino-N-[(1R)-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethyl]-3-(2-naphthyl)propionamide hydrochloride

Participants

Reaction Steps

{(1R)-1-{(1R)-1-(3-Methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylcarbamoyl}-2-(2-naphthyl)ethyl}carbamic acid tertbutyl ester (4.5 g, 8.99 mmol) was suspended in ethyl acetate (50 ml) and a saturated mixture of hydrogen chloride in ethyl acetate (45 ml) was added. After 3 h at 20° C., the reaction mixture was filtered to give 3.17 g of (2R)-2-amino-N-[(1R)-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethyl]-3-(2-naphthyl)propionamide hydrochloride.

Provenance & Evidence