反应详情

温度

60 °C

Thionyl chloride (5 ml) was added dropwise over 15 min. to a suspension of (R)-3-(2-naphthyl)alanine (5.0 g) in methanol (50 ml) at 35° C. After addition the mixture was heated at 60° C. for 1 h, cooled and the solvent removed in vacuo. Water (75 ml) and ethyl acetate (125 ml) were added and pH was adjusted to 8.5 with sodium carbonate. The organic phase was separated and dried (magnesium sulfate) to afford 4.86 g of (R)-3-(2-naphthyl)alanine methyl ester.

1. additionAfter addition the mixture
2. temperaturecooled
3. customthe solvent removed in vacuo
4. additionWater (75 ml) and ethyl acetate (125 ml) were added
5. customThe organic phase was separated
6. dry with materialdried (magnesium sulfate)