Benzylamine → HCID 22949386, compound

HRID 849863Notes

Reaction equation

HRID 849863 reaction equation
C(O[C:4]([C:6]1[N:10]=[C:9]([CH:11]([NH:19][CH3:20])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[O:8][N:7]=1)=[O:5])C.[CH2:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)C>[CH2:21]([NH:28][C:4]([C:6]1[N:10]=[C:9]([CH:11]([NH:19][CH3:20])[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[O:8][N:7]=1)=[O:5])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 53996724HCID 53996724, compound

Product 1

HCID 22949386HCID 22949386, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
20 °C

Procedure

5-(1-Methylamino-2-phenylethyl)-[1,2,4]oxadiazole-3-carboxylic acid ethylester (3.3 g, 9.0 mmol) was dissolved in ethanol (30 ml). Benzylamine (3 ml) was added and the reaction mixture was stirred for 18 h at 20° C. The reaction mixture was concentrated in vacuo and the residue was crystallised from ethanol to give 2.07 g of (R) 5-(1-methylamino-2-phenylethyl)-[1,2,4]oxadiazole-3-carboxylic acid benzylamide.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was crystallised from ethanol

Sources & evidence

ORD record
ord-6dc9339748a64f82a568908130fb8c1e
Source dataset
uspto-grants-2000_01
Patent number
US06013658

Reaction notes

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