HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 849918Generated: October 30, 2026
Trifluoroacetic acid → (Pyrole-2-carbonyl)-N-(benzyl)glycine
https://huagongshe.com/reaction/849918
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester | HCID 70020108 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (Pyrole-2-carbonyl)-N-(benzyl)glycine | HCID 18762404 | 94.1% |
Reaction Steps
To a solution containing 2.85 g (9.01 mmol) of (Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester in 50 mL of anhydrous dichloromethane cooled to 0° C. was added 25 mL of TFA dropwise. After 90 minutes an additional 25 mL of TFA was added and allowed to stir for 30 minutes. The mixture was evaporated in vacuo to afford 2.19 g of (Pyrole-2-carbonyl)-N-(benzyl)glycine as a tan solid. FAB MS [M+H]m/z; Calcd. 259, Found 259.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06015791 |
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| Source dataset | uspto-grants-2000_01 |
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| ORD ID | ord-bb8c30295a994a42802e5bc22ea2e947 |
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| Source note | uspto-grants-2000_01 |
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