HCID 19365524, compound → HCID 19365514, compound

Participants

Reaction Steps

First, 79 mg of 10% palladium/carbon was added to a solution of 0.30 g of 3-(4-fluoro-5-nitrophenyl)-1-methyl-6-trifluoromethyl-2-oxo-1,2-dihydropyrazine (present compound 1-13) in 12 ml of ethyl acetate under an atmosphere of nitrogen, which was then replaced with hydrogen under a pressure of 1 atm., and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was filtered through celite and concentrated. The residue was subjected to silica gel column chromatography, which afforded 0.13 g (yield, 47%) of 3-(5-amino-4-fluorophenyl)-1-methyl-6-trifluoromethyl-2-oxo-1,2-dihydropyrazine (present compound 1-19).

Provenance & Evidence