Water → HCID 19365504, compound

Participants

Reaction Steps

Then, 0.15 g of 3-(5-amino-2,4-dichlorophenyl)-1-methyl-6-trifluoromethyl-2-oxo-1,2-dihydropyrazine (present compound 1-334) was dissolved in 0.88 ml of pyridine, to which 52 μl of methanesulfonyl chloride was added dropwise, and the mixture was stirred at room temperature for 5 hours. After completion of the reaction, the reaction mixture was poured into water, followed by extraction with chloroform. The organic layer was washed with 2N hydrochloric acid, water, saturated sodium hydrogen-carbonate solution, and then saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography, which afforded 45 mg (yield, 25%) of 3-(2,4-dichloro-5-methanesulfonylaminophenyl)1-methyl-6-trifluoromethyl-2-oxo-1,2-dihydropyrazine (present compound 1-343; m.p., 189.2° C.).

Provenance & Evidence