Ethyl 2-bromopropionate → HCID 19365526, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.15 g of 3-(5-amino-2,4-dichlorophenyl)-1-methyl-6-trifluoromethyl-2-oxo-1,2-dihydropyrazine (present compound 1-334) and 172 μl of ethyl 2-bromopropionate was stirred at 150° C. for 3 hours. After completion of the reaction, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography, which afforded 92 mg (yield, 48%) of 3-{2,4-dichloro-5-[1-(ethoxycarbonyl)ethylamino]phenyl}-1-methyl-6-trifluoromethyl-2-oxo-1,2-dihydropyrazine (present compound 1-336).

Provenance & Evidence