6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline → HCID 54125635, compound

HRID 849976Notes

Reaction equation

HRID 849976 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]([Cl:20])[CH:14]=1.CO[CH:23](OC)[CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[Cl:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[F:19])[NH:12][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([NH:1][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)[CH:3]=2)[N:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 108807516-Amino-4-(3-chloro-4-fluoroanilino)quinazolineHCID 19365849HCID 19365849, compound

Product 1

HCID 54125635HCID 54125635, compoundYield 84%

Procedure

Using an analogous procedure to that described in Example 1, 6-amino-4-(3'-chloro-4'-fluoroanilino)quinazoline was reacted with 3-morpholinopropionaldehyde dimethyl acetal to give 4-(3'-chloro-4'-fluoroanilino)-6-(3-morpholinopropylarnino)quinazoline in 84% yield;

Sources & evidence

ORD record
ord-2547ae1c3d7d4029836cab1f36a72837
Source dataset
uspto-grants-2000_01
Patent number
US06015814

Reaction notes

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