HCID 19365852, compound → HCID 19365862, compound

HRID 849977Notes

Reaction equation

HRID 849977 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[F:29])[NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:16][C:17](=O)[CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[CH:14]=2)[N:9]=[CH:8][N:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[F:29])[NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[CH:14]=2)[N:9]=[CH:8][N:7]=1

Participants

3

Reactant 2

HCID 19365852HCID 19365852, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19365862HCID 19365862, compoundYield 58%

Procedure

Using an analogous procedure to that described in Example 1, 4-(3',4'-difluoroanilino)-6-(2-morpholinoacetamido)quinazoline was reduced with lithium aluminium hydride to give 4-(3',4'-difluoroanilino)-6-(2-morpholinoethylamino)quinazoline in 58% yield;

Sources & evidence

ORD record
ord-0670d0eea39449bca96a7252f691f8bd
Source dataset
uspto-grants-2000_01
Patent number
US06015814

Reaction notes

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