Nicotinic Acid → HCID 9929262, compound

Participants

Reaction Steps

1,3-Dicyclohexylcarbodiimide (97 g, 0.49 mol) and 4-(N,N-dimethylamino)pyridine (65 g, 0.53 mol) in methylene chloride (800 ml) were added with stirring to a solution of nicotinic acid (60 g, 0.49 mol) and z,z,z-octadeca-6,9,12-trienol (107 g, 0.41 mol) in methylene chloride (1200 ml). The progress of the reaction was monitored by tlc. On completion, the reaction mixture was filtered and the organic layer washed with 2M hydrochloric acid (500 ml) and water (3×500 ml), dried with magnesium sulphate and concentrated under reduced pressure. Purification by dry column chromatography using a gradient of ethyl acetate in hexane yielded z,z,z-octadeca-6,9,12-trienyl nicotinate as a pale yellow oil in 91% yield.

Provenance & Evidence