HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 23002648, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,5-Dimethyl-3-pyrroline | HCID 101066 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 2-Tert-butoxycarbonylamino-3-(4-cyano-phenyl)-propionic acid | HCID 4393346 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23002648 | HCID 23002648 | 52.4% |
Reaction Steps
2.1 g of 2-[(N-Boc)amino]-3-(4-cyanophenyl)propionic acid are mixed with 0.715 g of 2,5-dimethyl-2,5-dihydropyrrole in 10 ml of DMF, 3.9 g of BOP are added and the pH is adjusted to 7 by addition of Et3N. After stirring for 18 hours at RT, the mixture is evaporated to dryness and is then taken up in EtOAc, washed with NaHCO3 solution, with KHSO4 /K2SO4 and with saturated NaCl solution. The resulting solution is dried over Na2SO4 and then evaporated. The residue is taken up in an ether/hexane mixture and then dried over Na2SO4. 1.4 g of the expected compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06015812 |
| Source dataset | uspto-grants-2000_01 |
| ORD ID | ord-eeb7c52deaa74fa5990060b86027e20d |
| Source note | uspto-grants-2000_01 |