N-tert-butylhydroxylamine → HCID 85059727, compound

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Reaction Steps

2-(4-Methoxyphenylthio)-5-thiophenecarboxaldehyde from Step A was mixed with N-tert-butylhydroxylamine (10 g, 112.11 mmol), molecular sieves (4A, 50 g), silica gel (10 g) and chloroform (200 mL). The mixture was refluxed for 15 h, filtered and rotary evaporated. The residue obtained was purified by chromatography over silica gel eluting with hexanes/EtOAc (2:1, v:v) to provide a slightly pinkish powder (4.60 g, yield 16.8%), m.p.100.9° C. (Rf =0.19 on a silica gel plate using hexanes/EtOAc, 2:1, v:v, as the eluant).

Provenance & Evidence