反应详情

To an aqueous solution (33 ml) of 3-cyano-4-neopentyloxyaniline hydrochloride (21 g) were added sodium nitrite (6.7 g), stannous chloride dihydrate (59.5 g) and con. hydrochloric add (100 ml) with stirring under ice-cooling. After the completion of the reaction, precipitated crystals were collected by filtration The crystals were added to water, and the mixture was neutralized with aqueous sodium hydroxide solution, extracted with a mixed solvent of toluene and tert-butanol, washed with water and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 17 g of 3-cyano-4-neopentyloxy-phenylhydrazine.

1. additionhydrochloric add (100 ml)
2. temperaturecooling
3. customAfter the completion of the reaction
4. customprecipitated crystals
5. filtrationwere collected by filtration The crystals
6. additionwere added to water
7. extractionextracted with a mixed solvent of toluene and tert-butanol
8. washwashed with water
9. dry with materialdried over magnesium sulfate
10. customThe solvent was evaporated under reduced pressure