Acetic Acid → HCID 15407380, compound

Participants

Reaction Steps

To a solution (10 ml) of ethyl 5-amino-1-(3-cyano-4-isobutoxyphenyl)-pyrazole-4-carboxylate (1 g) in ethanol was added 5 N aqueous sodium hydroxide solution (1 ml) with string, and the mixture was refluxed under heating for 2 hours. After the completion of the reaction, the reaction mixture was poured into water, and the mixture was neutralized with acetic acid. The precipitated crystals were recrystallized from a mixed solvent of dioxane and water to give 0.4 g of 5-amino-1-(3-cyano-4-isobutoxyphenyl)pyrazole-4-carboxylic acid, melting point 204° C. (decomposition).

Provenance & Evidence