Isoamyl Nitrite → HCID 15407381, compound

Participants

Reaction Steps

Then, to a solution (16 ml) of ethyl 5-amino-1-(3-cyano-4-isobutoxyphenyl)pyrazole-4-carboxylate (1.64 g) obtained in Example 1 in tetrahydrofuran was added isoamyl nitrite (1.75 g) with stirring, and the mixture was refluxed under heating for 1.5 hours. After the completion of the reaction, the solvent was evaporated under reduced pressure and the obtained residue was recrystallized from ethyl alcohol to give 1.38 g of ethyl 1-(3-cyano-4-isobutoxyphenyl)pyrazole-4-carboxylate, melting point 138-139° C.

Provenance & Evidence