Acetic Acid → HCID 15407382, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (15 ml) of ethyl 1-(3-cyano-4-isobutoxyphenyl)pyrazole-4-carboxylate (1.38 g) in ethanol was added 1.75 N aqueous sodium hydroxide solution (3 ml) with stirring, and the mixture was heated at 80° C. for 30 minutes. After the completion of the reaction, the reaction mixture was poured into water and neutralized with acetic acid. The precipitated crystals were recrystallized from a mixed solvent of dioxane and water to give 0.7 g of 1-(3-cyano-4-isobutoxyphenyl)pyrazole-4-carboxylic acid, melting point 192-194° C.

Provenance & Evidence