Acetic Acid → HCID 15407387, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (15 ml) of ethyl 1-(4-butoxy-3-cyanophenyl)pyrazole-4-carboxylate (1.5 g) in ethanol was added 1.5 N aqueous sodium hydroxide solution (4 ml) with stirring, and the mixture was heated at 80° C. for 1 hour. After the completion of the reaction, the reaction mixture was poured into water and the mixture was neutralized with acetic acid. The precipitated crystals were recrystallized from ethyl acetate to give 0.75 g of 1-(4-butoxy-3-cyanophenyl)pyrazole-4-carboxylic acid, melting point 200-202° C.

Provenance & Evidence