Acetic Acid → 1-[3-Cyano-4-(1-ethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution (10 ml) of ethyl 1-(3-cyano-4-(1-ethylpropoxy)phenyl)pyrazole-4-carboxylate (0.8 g) in ethanol was added 2 N aqueous sodium hydroxide solution (1.5 ml) with stirring, and the mixture was heated at 80° C. for 30 minutes. After the completion of the reaction, the reaction mixture was poured into water and neutralized with acetic acid. The precipitated crystals were recrystallized from a mixed solvent of ethyl alcohol and water to give 0.6 g of 1-(3-cyano-4-(1-ethylpropoxy)phenyl)pyrazole-4-carboxylic acid, melting point 142-144° C.

Provenance & Evidence