Acetic Acid → 1-(3-Cyano-4-(3-methylbutoxy)phenyl)pyrazole-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution (15 ml) of ethyl 1-(3-cyano-4-(3-methylbutoxy)phenyl)pyrazole-4-carboxylate (1.6 g) in ethanol was added 1.5 N aqueous sodium hydroxide solution (4 ml) with stirring, and the mixture was heated at 80° C. for 30 minutes. After the completion of the reaction, the reaction mixture was poured into water and neutralized with acetic acid. The precipitated crystals were recrystallized from ethyl acetate to give 0.97 g of 1-(3-cyano-4-(3-methylbutoxy)phenyl)pyrazole-4-carboxylic acid, melting point 210-211° C.

Provenance & Evidence