Acetic Acid → HCID 15407393, compound

Participants

Reaction Steps

To a solution (17 ml) of ethyl 5-amino-1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylate (1.7 g) in ethanol was added 2 N aqueous sodium hydroxide solution (3 ml) with stirring, and the mixture was refluxed under heating for 2 hours. After the completion of the reaction, the reaction mixture was poured into water and neutralized with acetic acid. The precipitated crystals were recrystallized from a mixed solvent of dioxane and water to give 0.64 g of 5-amino-1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid, melting point 212° C. (decomposition).

Provenance & Evidence