Acetic Acid → HCID 15407395, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (10 ml) of ethyl 5-chloro-1-(3-cyano-4-isobutoxyphenyl)-pyrazole-4-carboxylate (1.05 g) in ethanol was added 1 N aqueous sodium hydroxide solution (3.6 ml) with string, and the mixture was heated at 60° C. for 1 hour. After the completion of the reaction, the reaction mixture was pouted into water and neutralized with acetic acid. The precipitated crystals were recrystallized from ethyl acetate to give 0.5 g of 5-chloro-1-(3-cyano-4-isobutoxyphenyl) pyrazole-4-carboxylic acid, melting point 216-218° C.

Provenance & Evidence