Acetic Acid → HCID 15407396, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (10 ml) of ethyl 5-chloro-1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylate (1.01 g) in ethanol was added 1 N aqueous sodium hydroxide solution (3.4 ml) with stirring, and the mixture was heated at 60° C. for 1 hour. After the completion of the reaction, the reaction mixture was poured into water and neutralized with acetic acid. The precipitated crystals were recrystallized from ethyl acetate to give 0.46 g of 5-chloro-1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid, melting point 212° C.

Provenance & Evidence