Hydrochloric Acid → HCID 19366047, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (20 ml) of ethyl 1-(4-(3-benzoyloxy-2,2-di methylpropoxy)-3-cyanophenyl) pyrazole-4-carboxylate (2.89 g) obtained in Example 37 in ethanol was added 1 N aqueous sodium hydroxide solution (14.2 ml) with stirring, and the mixture was heated at 50° C. for 3 hours. After the completion of the reaction, the reaction mixture was poured into water and neutralized with 1 N hydrochloric acid (15 ml). The precipitated crystals were recrystallized from ethyl acetate to give 0.3 g of 1-(3-cyano-4-(2,2-dimethyl 3-hydroxypropoxy)phenyl)pyrazole-4-carboxylic acid, melting point 188-190° C.

Provenance & Evidence