Hydrochloric Acid → HCID 19366043, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (6.4 ml) of ethyl 1-(3-cyano-4-(2-methyl-2-methoxy-carbonylpropoxy)phenyl)pyrazole-4-carboxylate (0.64 g) obtained in Example 39 in ethanol was added 2 N aqueous sodium hydroxide solution (2.15 ml) with stirring, and the mixture was heated at 50° C. for 8 hours. After the completion of the reaction, the reaction mxture was poured into water and neutralized with 1 N hydrochloric acid (3.8 ml). The precipitated crystals were recrystallized from a mixed solvent of ethyl alcohol and water to give 0.26 g of 1-(4-(2-carboxy 2-methylpropoxy)-3cyanophenyl)pyrazole-4-carboxylic acid, melting point 230-233° C.

Provenance & Evidence