HCID 19366011, compound → HCID 178435840, compound

Participants

Reaction Steps

A solution of 2-(2,4-difluorophenyl)-3-(4-[1-benzyl-1,2,3-triazol-5-yl]phenyl)-1-(1,2,4-triazol-1-yl)-3-buten-2-ol(0.15 g,0.3 mmol-see Preparation 43) in methanol (100 ml) was hydrogenated at 50 psi (333 kPa) pressure over 10% palladium on charcoal (0.1 g) for 18 hours at 100° C. The cooled mixture was filtered through "Arbocel" and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on silica by elution with dichloromethane/methanol (19:1). Fractions containing the desired product were combined and evaporated under reduced pressure to yield the title compound as a gum (0.1 g, 81%). The product was a mixture of diastereomers by NMR.

Provenance & Evidence