Hydrogen Peroxide → HCID 56990342, compound

Participants

Reaction Steps

A solution of (2R,3S)-2-(2,4-difluorophenyl)-3-(4-[3-mercapto-4-methyl-1,2,4-triazol-5-yl]phenyl)-1-(1,2,4-triazol-1-yl)butan-2-ol (0.6 g, 1.4 mmol) in acetic acid (10 ml) was heated under reflux and treated with aqueous hydrogen peroxide (30%, 0.5 ml, 8 mmol) dropwise. After a further 0.5 hour at reflux, the mixture was cooled to room temperature and evaporated under reduced pressure. The residue was partitioned between ethyl acetate (20 ml) and saturated sodium bicarbonate solution (20 ml). The organic phase was washed with brine (20 ml), dried (Na2SO4) and evaporated under reduced pressure.

Provenance & Evidence