反应详情

The title compound was prepared from 5-bromo-2-ethylpyridine (Preparation 65) and 1,2,3-triazole by a similar method to Preparation 1. The regioisomeric product were separated by column chromatography on silica by gradient elution with ethyl acetate/hexane (1:1→1:0). Fractions containing the title compound eluted first, these were combined and evaporated under reduced pressure to yield an oil, which was distilled b.p.135° C. @ 0.05 mmHg (Kugelrohr).

1. customThe regioisomeric product were separated by column chromatography on silica by gradient elution with ethyl acetate/hexane (1:1→1:0)
2. additionFractions containing the title compound
3. washeluted first
4. customevaporated under reduced pressure
5. customto yield an oil, which
6. distillationwas distilled b.p.135° C. @ 0.05 mmHg (Kugelrohr)