Sodium Hydroxide → HCID 54549528, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-methoxy-4-(methylcarbamoyl)-cinnamate (300 mg) in methanol was added 1H aqueous sodium hydroxide solution (1.5 ml) at ambient temperature, and the mixture was stirred for 5 hours at 50° C. The solvent was removed, and water was added thereto. The mixture was washed with diethyl ether and adjusted to pH 4 with 1N hydrochloric acid. The resulting precipitate was collected by filtration and washed with water to give 3-methoxy-4-(methylcarbamoyl)-cinnamic acid (250 mg).

Provenance & Evidence