HCID 11123605, compound → HCID 15291043, compound

HRID 850224Notes

Reaction equation

HRID 850224 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:6]([N:8]([CH3:24])[C@H:9]([C:13]([N:15]1[CH2:23][CH2:22][CH2:21][C@H:16]1[C:17]([O:19][CH3:20])=[O:18])=[O:14])[CH:10]([CH3:12])[CH3:11])=[O:7])[CH:3]([CH3:5])[CH3:4]>CO.[Pd]>[NH2:1][C@H:2]([C:6]([N:8]([CH3:24])[C@H:9]([C:13]([N:15]1[CH2:23][CH2:22][CH2:21][C@H:16]1[C:17]([O:19][CH3:20])=[O:18])=[O:14])[CH:10]([CH3:12])[CH3:11])=[O:7])[CH:3]([CH3:4])[CH3:5]

Participants

4

Reactant 1

HCID 11123605HCID 11123605, compound

Product 1

HCID 15291043HCID 15291043, compoundYield 104.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

29.3 g (61.6 mmol) of Z-Val-MeVal-Pro-OMe were dissolved in 230 ml methanol. After addition of 1.15 g 10% Palladium/charcoal, the reaction mixture was hydrogenated. Filtration and evaporation to dryness yielded 21.96 g of the product.

Workup

  1. filtrationFiltration and evaporation to dryness

Sources & evidence

ORD record
ord-6db5de0a492747b8b098d60f8ced62d6
Source dataset
uspto-grants-2000_01
Patent number
US06015790

Reaction notes

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