Hydrochloric Acid → HCID 53724298, compound

Participants

Reaction Steps

To a solution of 25 mmol of 1-(2-fluoro-4-dimethylbutylsilyloxyphenyl)-2-iodoethyne in 50 ml of tetrahydrofuran were added copper cyanide and lithium bromide and the solution was reacted under reflux heating for 3 hours. After completion of the reaction, the solution was poured into a hydrochloric acid solution of ferric chloride and extracted with toluene. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford 20 mmol of 2-fluoro-4-hydroxyphenylpropiolonitrile as a colourless solid.

Provenance & Evidence