2,4-Di(benzyloxycarbonyl)butyl(methyl)-O-benzylphosphinic acid → HCID 10198410, compound

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Reaction Steps

2,4-di(benzyloxycarbonyl)butyl(methyl)-O-benzylphosphinic acid (0.8 g, 1.6 mmol) in 20 mL of water containing 100 mg of 10% Pd/C was hydrogenated at 40 psi for 4 hours. The mixture was filtered over a pad of Celite and evaporated at high vacuum to give 2-[(methylhydroxyphosphinyl)methyl]pentanedioic acid (4, R=CH3, 0.28 g), 78% as a clear and colorless viscous oil.

Provenance & Evidence