HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Trimetrexate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Sodium Pyrosulfite | HCID 656671 | — |
| Reactant | HCID 86755089 | HCID 86755089 | — |
| Solvent | Water | HCID 962 | — |
| Product | Trimetrexate | HCID 5583 | — |
Reaction Steps
The reactor is charged with 41.5 L of n-butanol and 10.4 L of deionized water. 6.3 kg of crude trimetrexate acetate is then added. Then, 3 g of sodium metabisulfite, 0.65 L of ammonia, 1 kg of tonsil and 1 kg of Supercel are added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06017922 |
| Source dataset | uspto-grants-2000_01 |
| ORD ID | ord-e6b671a7c6ff4122a33c0fcb772448ff |
| Source note | uspto-grants-2000_01 |