HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → (3,5-Di-tert-butyl-4-hydroxy-phenyl)-[(N'-methyl)-N-piperazinyl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 2-bromo-(3,5-di-t-butyl-4-hydroxyphenyl)-acetate | HCID 12018252 | — |
| Product | (3,5-Di-tert-butyl-4-hydroxy-phenyl)-[(N'-methyl)-N-piperazinyl]-acetic acid ethyl ester | HCID 9908454 | — |
Reaction Steps
The compound was synthesized as in Example 17 from Intermediate 11 (2.3 g, 6.2 mmol) and N-methylpiperazine (1.60 g, 16 mmol). This gave 1.1 g (46%) of pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06017918 |
| Source dataset | uspto-grants-2000_01 |
| ORD ID | ord-474927ea032f46fda73ee0b23336d196 |
| Source note | uspto-grants-2000_01 |