Morpholine → Diethyl-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-(N-morpholinyl)-acetamide

HRID 850342Notes

Reaction equation

HRID 850342 reaction equation
[CH2:1]([N:3]([CH2:22][CH3:23])[C:4](=[O:21])[CH:5]=[C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9](=[O:16])[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:7]1)[CH3:2].[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[CH2:22]([N:3]([CH2:1][CH3:2])[C:4](=[O:21])[CH:5]([C:6]1[CH:11]=[C:10]([C:12]([CH3:14])([CH3:15])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)[N:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)[CH3:23]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 22019858N,N-Diethyl-2-(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)acetamide

Product 1

HCID 9844171Diethyl-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-(N-morpholinyl)-acetamide

Procedure

Synthesized as in Example 51 from Intermediate 21 (1.84 g, 5.8 mmol) and morpholine (1.06 g, 12.2 mmol). This gave 1.65 g (70%) of pure product.

Sources & evidence

ORD record
ord-5d978c8273db42edba1519744655aa31
Source dataset
uspto-grants-2000_01
Patent number
US06017918

Reaction notes

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