2,2,4-Trimethyl-1,2-dihydroquinolin-7-amine → HCID 10631958, compound

Participants

Reaction Steps

Removal of the Boc protective group of 7-tert-butyloxycarbamoyl-1,2-dihydro-2,2,4,8-tetramethylquinoline (400 mg, 1.32 mmol) was effected in the manner similar to that described for 7-amino-1,2-dihydro-2,2,4-trimethylquinoline (EXAMPLE 13), affording 267 mg (quantitative) of the desired aniline as a light reddish oil. Data for 7-amino-1,2-dihydro-2,2,4,8-tetramethylquinoline: 1H NMR (400 MHz, CDCl3) 6.82 (d, 1H, J=8.2 Hz, 5-H), 6.08 (d, 1H, J=8.1 Hz, 6-H), 5.15 (d, 1H, J=1.2 Hz, 3-H), 3.56 (br s, 3H, NH2, NH), 1.95 (d, 3H, J=1.2 Hz, 4-CH3), 1.91 (s, 3H, 8-CH3), 1.27 [s, 6H, 2-(CH3)2 ].

Provenance & Evidence