関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Cinnamoylbenzene | HCID 7189 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Glycol monoethyl ether | HCID 8076 | — |
| 生成物 | Dodecanenitrile | HCID 17092 | — |
反応手順
To the chalcone, 187, (17.95 g, 54.7) mmol) in 2-ethoxyethanol (150 mL) at 55° C. was added acetic acid (4 mL) followed by slow addition of potassium cyanide (5.3 g, 81 mmol) in water. The solution was stirred at 105° C. for 0.25 hour. The solution was cooled and treated with water (25 mL). The mixture was filtered to collect the solid. The solid was washed repeatedly with 70% ethanol (50 mL), air dried, and then dried in vacuo to give the nitrile 12.7 g (68%) as a yellow solid. The nitrile was identified by 1H NMR, IR, MS, and microanalysis.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06017916 |
|---|
| 出典データセット | uspto-grants-2000_01 |
|---|
| ORD ID | ord-09c379ede3af4a9fb74195064cc2b22e |
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| 出典メモ | uspto-grants-2000_01 |
|---|
