Lithium hydroxide, monohydrate → 2-[4-Chloro-2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]phenoxy]acetic acid

Participants

Reaction Steps

The product from Step D was suspended in 1:1:1 methanol/THF/water (9 ml) and lithium hydroxide hydrate (126 mg, 3.0 mmol) was added. After 16 h the volatiles were removed in vacuo and the solution was diluted with water and was washed with ethyl acetate, adding sufficient brine to disperse the emulsion. The aqueous layer was acidified with 5% KHSO4 solution and was extracted with methylene chloride which was then dried (Na2SO4) and evaporated in vacuo to give the title compound as a solid:

Provenance & Evidence