HCID 19363338, compound → HCID 19363376, compound

Participants

Reaction Steps

4-Chloro-7-methoxy-8-pentyloxyquinoline-3-carbamic acid (101 mg, 0.312 mmol) and methanol (10 ml) were mixed, and 10% palladium-carbon catalyst (30 mg) was added to this solution. The mixture was stirred at room temperature for 5 hours in a stream of hydrogen. The palladium-carbon catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1-6/4) to give 7-methoxy-8-pentyloxyquinoline-3-carbamic acid (74.6 mg, 83%) as yellow crystals.

Provenance & Evidence