Pyridine → HCID 19363467, compound

Participants

Reaction Steps

4-Amino-3-pentyloxybenzoic acid (200 mg, 0.90 mmol), methylene chloride (5 ml) and pyridine (0.081 ml, 1.0 mmol) were mixed, and valeryl chloride (0.11 ml, 0.90 mmol) was added to this solution. The mixture was stirred at room temperature for 0.5 hour. Water was added to the reaction mixture, and the aqueous layer was extracted 3 times with ethyl acetate (5 ml). The organic layers were combined, washed with saturated brine (10 ml), and dried over anhydrous magnesium sulfate. The drying agent was filtered off and the filtrate was concentrated under reduced pressure. The obtained crude crystals were washed with hexane to give 4-pentanoylamino-3-pentyloxybenzoic acid (109.5 mg, 400%) as colorless crystals.

Provenance & Evidence