HCID 19363263, compound → HCID 19363347, compound

Participants

Reaction Steps

[6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-3-methoxy-2-pentyloxyphenyl]-methanol (4.69 g, 0.014 mmol, 1 eq) was dissolved in 3N hydrochloric acid (50 ml), and the solution was stirred under heating for 3 hours. After the completion of the reaction, the mixture was cooled to room temperature and extracted twice with diethyl ether (50 ml). The organic layers were combined, washed with saturated brine (100 ml) and dried over anhydrous sodium sulfate. The drying agent was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (n-hexane/ethyl acetate=2/1) to give 5-methoxy-4-pentyloxy-3H-isobenzofuran-1-one (3.4 g, 82.4%) as a colorless oil.

Provenance & Evidence