HCID 19363419, compound → HCID 19363480, compound

Participants

Reaction Steps

2-[2-(4-Benzyloxyphenyl)ethyl]-5-methoxy-4-pentyloxy-2,3-dihydroisoindol-1-one (125.9 mg, 0.274 mmol, 1.0 eq) was dissolved in ethyl acetate (10 ml), and 100% palladium-carbon catalyst (80 mg, water content 50%) was added. The mixture was stirred in a stream of hydrogen for 3 hours. After the completion of the reaction, the mixture was filtered through Celite and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (ethyl acetate/hexane=1/1) to give 2-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-4-pentyloxy-2,3-dihydroisoindol-1-one (5 mg, 74.1%) as colorless crystals.

Provenance & Evidence