Ethanol → HCID 131721613, compound

Participants

Reaction Steps

2-Amino-4-methoxy-N-[2-(4-nitrophenyl)ethyl]-3-pentyloxydenzamide (200 mg, 0.498 mmol) obtained in Example 2-46, ethanol (3 ml) and acetyl acetone (0.13 ml, 1.25 mmol) were mixed, and one drop of concentrated hydrochloric acid was added to this solution. The mixture was refluxed under heating for 2.5 hours, and ethyl acetate (30 ml) and saturated brine (30 ml) were added to separate the organic layer. This organic layer was washed successively with saturated aqueous sodium hydrogencarbonate solution (20 ml) and saturated brine (20 ml), and dried over anhydrous magnesium sulfate. The drying agent was filtered off and the filtrate was concentrated under reduced pressure to give a crude product of 7-methoxy-2-methyl-3-[2-(4-nitrophenyl)ethyl]-8-pentyloxy-3H quinazolin A one.

Provenance & Evidence