Dimethylformamide → HCID 19363314, compound

Participants

Reaction Steps

2-Amino-4-methoxy-3-pentyloxy-N-(2-pyridin-4-ylethyl)benzamide (200 mg, 0.560 mmol) obtained in Example 2-61, carbon disulfide (0.6 ml), 1,8-diazabicyclo [5.4.0]-7-undecene (0.0837 ml, 0.56 mmol) and DMF (1.0 ml) were mixed, and this mixture was refluxed under heating for 4 hours. Ethyl acetate (4 ml) and water were added to this reaction mixture. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution (5 ml) and saturated brine (5 ml), and dried over anhydrous magnesium sulfate. The drying agent was filtered off and the filtrate was concentrated under reduced pressure. The obtained residue was subjected to column chromatography on silica gel (chloroform/methanol=10/1) and recryst alli ztion from ethyl acetate to give 7-methoxy-8-pentyloxy-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (24 mg, 11%) as colorless crystals.

Provenance & Evidence