反应详情

The crude product of 1-(6-methoxy-5-pentyloxy-3,4-dihydro-1H-isoquinolin-2-yl)-2 -(4-nitrophenyl)ethanone obtained in Example 7-50 was dissolved in ethanol (4 ml), and 10% palladium-carbon catalyst (38 mg) was added to this solution. The reaction mixture was stirred in a stream of hydrogen for 3 hours, and then filtered. The solvent was concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (hexane/ethyl acetate=1/2) to give 2-(4-aminophenyl)-1-(6-methoxy-5-pentyloxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone (159 mg, 89% in 2 steps) as a colorless oil.

1. filtrationfiltered
2. concentrationThe solvent was concentrated under reduced pressure
3. customThe obtained residue was purified by column chromatography on silica gel (hexane/ethyl acetate=1/2)