Hydrochloric Acid → HCID 11091658, compound

Participants

Reaction Steps

HCl gas was rapidly bubbled through a solution of 2-10 (4.0 g, 7.2 mmol) in dioxane (160 ml) at 0° C. for 10 minutes. After 30 minutes, the solution was purged with argon for 30 minutes. The solution was concentrated to give the amine 2-11 as a yellow solid. 1H NMR (300 MHz, CDCl3) δ 7.91 (s, 1H), 7.40 (d, J=7.0 Hz, 1H), 7.23 (d, J=7.6 Hz, 1H), 7.10 (m,2H), 6.56 (d, J=6.1 Hz, 1H), 4.58 (m, 2H), 4.04 (m,2H), 3.49 (m, 4H), 3.19 (m, 4H), 2.90 (m, 2H), 2.79 (m, 2H), 2.30 (m, 2H), 1.98(m, 2H), 1.85 (m, 5H), 1.15 (t, J=7.1 Hz, 3H).

Provenance & Evidence