Benzylamine → HCID 54083939, compound

HRID 850613Notes

Reaction equation

HRID 850613 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH:5]=[CH:6][C:7]1[CH:8]=[N:9][C:10]([N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH3:14])=[CH:11][CH:12]=1)[CH3:2].[CH2:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH:6]([NH:30][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:7]1[CH:8]=[N:9][C:10]([N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH3:14])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 57293438HCID 57293438, compound

Product 1

HCID 54083939HCID 54083939, compound

Conditions

Temperature
95 °C

Procedure

A mixture of 11-4 (1.7 g, 5.6 mmol) and benzylamine (8 mL, 73.2 mmol) was heated in a sealed-tube at 95° C. for 24 hr. The crude reaction mixture was purified using silica gel flash chromatography (EtOAc/hexanes 1:3 to 1:1) to afford the desired product 11-5 as an oil.

Workup

  1. customThe crude reaction mixture
  2. customwas purified

Sources & evidence

ORD record
ord-6946bd83b7ae4daf8a56156e6c72c98f
Source dataset
uspto-grants-2000_01
Patent number
US06017926

Reaction notes

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