1,4-Dioxane → HCID 53838529, compound

Participants

Reaction Steps

To a stirred solution of 20-10 (0.80 g, 1.57 mmol) and diisopropylethylamine (0.823 mL, 4.72 mmol) in dichloromethane (10 mL) at 0° C. was added p-nitrophenyl chloroformate (0.333 g, 1.65 mmol). The solution stirred for 30 minutes and dioxane (10 mL) was added, then refluxed for 4 hours. EtOAc (100 mL) was added and the organics were washed with 10% K2CO3, dried, and concentrated in vacuo. The residue was chromatographed (silica gel, [70:20:10 CHCl3 /EtOAc/MeOH]) to give 20-11.

Provenance & Evidence