4-Methoxybenzylamine → HCID 70255147, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Methoxybenzylamine	HCID 75452	—
Reactant	Sodium t-butoxide	HCID 23676156	—
Reactant	HCID 53838529	HCID 53838529	—
Catalyst	Ferrocene-1,1'-bis-(diphenylphosphine)	HCID 635956	—
Catalyst	(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium	HCID 6505921	—
Solvent	Toluene	HCID 1140	—
Product	HCID 70255147	HCID 70255147	—

Reaction Conditions

Temperature	110 °C

Reaction Steps

To a stirred solution of 20-11 (0.075 g, 0.142 mmol) in toluene (3 mL) was added Pd(DBA)2 (0.0041 g, 0.0071 mmol), DPPF (0.0039 g, 0.0071 mmol), and NaOt-Bu (0.0163 g, 0.170 mmol) followed by p-methoxybenzylamine (0.0204 mL, 0.156 mmol). The resulting solution was heated at 110° C. for 2 hours. The solution was cooled and the solvent was removed in vacuo. The product was purified by silica gel chromatography (10% EtOH/EtOAc) to give (20-12.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06017926
Source dataset	uspto-grants-2000_01
ORD ID	ord-095c85b651c74d648480e80eb02e88b9
Source note	uspto-grants-2000_01